In the oil and gas production industry carbon steel tubing and piping are susceptible to erosion-corrosion damage due to the erosive and corrosive nature of the flow. The combined effect of sand erosion and corrosion can be very significant. This paper presents a mechanistic approach for predicting metal loss due to sand erosion and CO2 corrosion of carbon steel. This approach accounts for iron carbonate (FeCO3) scale formation in multiphase flow by modeling the competition between scale growth by precipitation and scale removal by erosion. Models from the literature for quantifying iron carbonate scale precipitation and growth rates and diffusion rates of cathodic reactants and corrosion product species through iron carbonate scale have been adapted to this purpose. The solid particle erosion resistance of FeCO3 scales produced under a range of environmental and flow conditions has been characterized by direct impingement experiments. Literature and laboratory results along with a CO2 corrosion rate prediction model and a sand erosion rate prediction model developed by the Erosion/Corrosion Research Center (E/CRC) at The University of Tulsa have been integrated into a single mechanistic model for predicting erosion-corrosion in multiphase flow under steady-state conditions.