The influence of plastic strain combined with sour service on the resistance of heavy-wall SAWL large-diameter pipes of grade X65 and X70 to HIC (Hydrogen Induced Cracking) and SSC (sulphide stress cracking) has been investigated. Plastic strain has been applied on longitudinal test specimens from base metal and weld of an X65 pipe by four-point bending. SSC four-point bend tests have been performed on these 15 mm thick specimens of the pipe at an additional elastic stress of 80 % of the specified minimum yield strength of the base material at dedicated fit-for-service test conditions in the presence of 0.2 bar H2S and at various pH levels. For comparison in-situ straining was also simulated. For that purpose slow-strain rate tests have been performed at 1 bar and 0.2 bar H2S partial pressure in order to determine the in-situ strain limits of the material. The influence of pre-straining and aging has been investigated on the X70 pipe. The material has been pre-strained to 2 % and aged for 1 h. HIC and SSC four-point bend tests have been performed at 1 bar H2S. The test results are discussed and compared to non stressed material.