Decarbonization of energy systems requires transitioning existing energy systems to use with low carbon sources. As part of such transitions, existing natural gas networks are being evaluated for compatibility with transporting hydrogen – natural gas (H2 – NG) blends, as a steppingstone to potentially transport 100% hydrogen. Utilizing the existing networks provides opportunities for time and cost-efficient transitions overcoming the high cost of, and public resistance to, building new infrastructures. A comprehensive, system-wide assessment of existing infrastructure is the first step in determining the feasibility of such transitions, from both technical and safety aspects. Such an assessment should consider the potential challenges that are generally recognized with hydrogen or hydrogen - natural gas blends and evaluate potential impacts on the materials, operational, and safety and system performance characteristics of the systems. A thorough assessment should encompass a study of the entire network including the feasibility from multiple facets in order to provide an acceptable range of H2 concentration (H2%) to be safely blended with natural gas without substantial modification to the existing infrastructure. This should include the compatibility of the material and equipment throughout the entire network with H2, considering material interaction, system integrity, process and performance, equipment accuracy and functionality, chemical compatibility, storage and handling, and customer (i.e., end-use) compatibility. The current paper portrays the steps and challenges that should be considered in the feasibility assessment of each material population, end use and equipment population at the distribution level.