When considering longer term operations of nuclear power plants beyond 80 years of operation, EPRI has taken the approach of forming a solid technical basis based on key aging parameters and not based simply on age (in years) of the plant. These key parameters indicate when a system, structure, or component may need additional analysis, consideration or even inspections. When these key parameters reach a limit to where additional aging management actions are needed, EPRI has a provided a toolbox of options to monitor components, assess and estimate remaining life, to mitigate effects during ongoing operations and options to provide specific repair or replacement of certain critical components. This basis has been developed based upon decades of accumulated and documented past research, operating experience, and inspection results. When dealing with the uncertainty of operating a nuclear power plant past 80 years, EPRI has implemented an approach to use Issue Management Tables to capture knowledge gaps for aging management of post 80 years of operations. These knowledge gaps relate to condition monitoring to assess the ongoing viability of components, advanced modeling and digital twins to predict remaining useful life, advanced repair technologies, and replacement strategies. This paper will provide an overview of the EPRI approach and will specifically focus on the key issues calling for future research in the areas of reactor vessel and internals, cables, and concrete.