Ni-base precipitation hardened (PH) superalloys are used in oil and gas applications where a combination of corrosion resistance and excellent mechanical properties are required. Hydrogen is often present in these situations due to the need to cathodically protect components from corrosion. These alloys have been shown to be susceptible to hydrogen environment assisted cracking (HEAC) leading to early failures in the field. In this study alloy UNS N07716 and UNS N07718 were examined in various conditions to further understand the role of microstructure and processing on the severity of degradation caused by hydrogen in Ni-base PH superalloys. Both alloys are well suited for applications requiring a high yield strength and superb corrosion resistance.The rising step load method was employed on pre-cracked single edge notch bend (SEN(B)) specimens to measure the threshold stress intensity factor for subcritical crack growth (KTh). Specimens were exposed to hydrogen via application of in-situ cathodic polarization in 3.5 wt% NaCl aqueous solution. This method has shown the ability to differentiate between HEAC susceptibility of Ni-base PH superalloys and provides a fracture mechanics based measure useful for component design. Alloy processing variations included cold drawing and heat treatments to intentionally modify grain size degree of precipitation and precipitate location. Material in the condition defined by API Specification 6A was also tested for comparison. Results indicated the severity of hydrogen damage was affected by the alterations in processing and microstructure as well as the measured strength of the material.