In the realm of corrosion management, corrosion under insulation (CUI) poses significant challenges, particularly for facilities operating in cryogenic service. A comprehensive approach to understanding and mitigating CUI risks is crucial for ensuring asset integrity, safety, and operational efficiency. This paper presents an in-depth case study of a natural gas liquids (NGL) fractionation facility, demonstrating the successful implementation of a holistic CUI management strategy applicable to a broader industry context. Notably, the facility has faced unique challenges, as some circuits have not been shut down or inspected for the past 40 years. The paper details the extensive work carried out, encompassing risk mapping, mitigation strategies, inspection planning and prioritization, and repair planning. By adopting a systematic approach, the study effectively identifies and addresses CUI risks in the facility's cryogenic service operations. The results of this research contribute to the existing body of knowledge on CUI management in cryogenic service, offering a recommended path forward for the industry to tackle CUI-related issues. By showcasing a comprehensive and adaptable approach, this paper holds great potential to foster increased safety, reliability, and efficiency in the corrosion industry, paving the way for future research and collaboration.