During production in the Permian Area, one of the most impactful operational issues is scale formation and deposition, which can be related to CaCO3, CaSO4, BaSO4, FeS, etc. Scale can occur anywhere from downhole reservoirs and wellbores to topside facilities. Based on different scale formation species, operation conditions, and system requirements, scale treatment strategies will vary and can include the following aspects: • For downhole conditions, either continuous injection or squeeze application can be applied. Squeeze treatments can effectively prevent carbonate and sulfate scales for typically at least 6 to 12 months and help to reduce the amount of solid deposition downhole and in surface facilities. • For surface facilities, continuous injection is usually applied. Scale inhibitors should be compatible with high TDS & high calcium waters to avoid pseudo scale formation, causing increased usage of inhibitors and even blockage of the system. • Iron sulfide (FeS) scale can be controlled by chelators, i.e., Tetrakis(hydroxymethyl)phosphonium sulfate (THPS), though typically should be combined with corrosion control and even H2S scavenging treatment to reduce FeS solid deposition. This paper presents case histories from the Permian Area, including general scale issues, FeS deposition cases, and guidance for selecting suitable treatment programs to provide insights on future scale treatments in similar operations.