Application of an effective prevention program for microbiological influenced corrosion (MIC) can be as varied as there are types of systems that are susceptible to this corrosion process. Fire protection systems by their design, are typically stagnant reservoirs of untreated water that provide ideal environmental conditions for MIC to proliferate, resulting in expensive but necessary repairs. There is particular concern when these systems are installed over manufacturing cleanroom space, with the potential of eventual pipe failure causing major impacts to production. Since absolute effectiveness of any treatment program in fire sprinkler systems would take years to validate, there is evidence to believe that through application of certain piping arrangements in the system and a consistent treatment program, formation of MIC can be prevented or delayed and pipe repairs postponed for scheduled downtime. Keywords: microbiological influenced corrosion, ( MIC), fire protection, sprinklers, treatment, preventative maintenance.