The adoption of renewable feedstocks by refiners is driven by a variety of factors, including regulatory compliance, sustainability, and diversification of their product portfolio. However, the introduction of these feedstocks poses significant risks due to their chemical differences compared to traditional crude feedstocks. To address these risks, many refiners have undertaken costly conversion projects to protect their plants from damage caused by these new feedstocks. In addition, refiners are increasingly turning to online integrity sensors to quickly detect corrosion and mitigate unwanted risk, helping to ensure that their critical assets remain healthy and reliable. With these strategies in place, refiners can effectively manage the challenges of incorporating “bio” feedstocks into their refining processes while ensuring the safety and longevity of their equipment. This paper will feature a case study from a major European refiner who have converted an old hydroprocessing unit into producing sustainable fuels from 100% bio feedstock.