Marine growth had become a challenging issue to offshore industry, particularly at water injection system and immersed structures. Its presence will affect the performance of the facilities by reducing the efficiency of heat exchangers and causing excessive increase in weight to offshore structures and equipment. The effect could consequently lead to production deferment. Existing methods to control marine growth such as using chemical treatment (biocide and tributyltin) and mechanical treatment (mechanical wiper/shutter) do not seem to have been effective or environmental-friendly while at the same time, consuming high-power costs. In this research study, the focus is to assess extracted anti-fouling compound from identified potential marine resources in preventing marine growth at static structure application. The research methodology will consist of extraction of the compounds, anti-bacterial activity screening and anti-fouling analysis as part of preliminary screening to test efficiency in preventing the growth of barnacles specifically. The selected compounds from screening incorporate into a suitable anti-fouling paint. The efficiency of selected compound is further evaluated by continuing with field exposure at identify site location located at south china sea. During the field exposure, small coupons are coated according to PETRONAS technical standard requirement and exposed for duration of a month. The results from a month field exposure show developed anti-fouling compound managed to prevent growth of barnacle. The success formulation from a month exposure is further evaluated at two type water environments which are warm and cold for duration of six months. Outcome from the exposure shows positive result. In conclusion, the developed anti-fouling compounds have potential to prevent marine growth, specifically barnacle growth.