When chemical process systems require extremely harsh or demanding environments, material selection is critical for providing longevity and preventing downtime. For systems utilizing exceedingly low or high pH chemicals, fluoropolymers are often an excellent choice to prevent corrosion in a system. The strong carbon-fluorine bond allows fluoropolymers to thrive in areas where other materials would be subject to failures. Strong acids are handled exceptionally well by many fluoropolymers, and certain copolymerization reactions with materials such as PVDF can provide a material that holds up to even more challenging situations. This paper will summarize the most commonly used fluoropolymers in the industry, as well as discuss applications where fluoropolymers are used. The paper will also detail why fluoropolymers can resist exceptionally aggressive chemicals, and how PVDF-HFP copolymers improve the corrosion resistance of both low and high pH environments. Case studies will also be provided.