Coiled Tubing is being extensively used for intervention and completion operations in sour wells. A sour environment implies an integrity risk to carbon and low alloy steels; this risk increases with higher strength materials which is the direction of the market for coiled tubing.For service in sour environments the use of inhibition is common and recommended; however an acceptable inherent resistance to different types of cracking is desired to limit the risks in the case of a temporary non proper inhibition.This paper summarizes results and outcomes of a sour performance evaluation program involving several grades of coiled tubing (specified minimum yield strengths from 80 to 125 ksi) where the impact of chemistry microstructure and heat treatment of base material and welds was studied. During the evaluation different type of tests were carried out including C-ring tests low-cycle fatigue after sour exposure and Hydrogen Induced Cracking.