This paper summarizes the methodologies appropriate for crack growth rate (CGR) characterization on neutron-irradiated alloys. A set of procedures were developed and applied for testing CGRs of neutron-irradiated stainless steel in the Irradiated Materials Testing Complex (IMTC) at the University of Michigan. The DCPD technique was used to monitor the evolution of crack growth under various loading and environmental conditions throughout a CGR test up to 3000 hours. The high resolution of DCPD the application of a correction factor to crack length and dK/da control when changing K improved the accuracy of crack growth monitoring. A procedure for mounting a RCT sample in the hot cell using remote manipulator operation was also developed. Precision design of fixtures helped to overcome the difficulties of spot-welding thin DCPD wires using manipulators. On-the-fly environmental change from BWR NWC to BWR HWC and then to PWR water at 288°C and 320°C was successfully conducted and constant K control was maintained throughout the test. As a result a complete history of well-controlled crack growth in a neutron-irradiated round compact tension (RCT) sample was reported for the first time.